"The 37-year-old woman sustained severe multiple injuries. Unfortunately there was nothing paramedics could do for her and she was declared dead on the scene. The jaws of life had to be used to remove her body from the vehicle," said ER24 spokesperson Chitra Bodasing.
She said four bus passengers were treated for minor injuries and transported to the Edendale Hospital. The bus driver did not sustain injuries.
The accident occurred on the R56 between Richmond and Pietermaritzburg on Wednesday night.
In Benoni, two people are in a critical condition following a collision late on Wednesday night between a taxi and bakkie in Du Randt Road, Putfontein.
Paramedics arrived on scene and found people lying on the road and in the veld. The taxi, with 16 occupants, and the bakkie, with one occupant, were involved in a head-on collision.
The taxi driver sustained multiple injuries. Paramedics treated him on scene and he was later airlifted to hospital.
One of his passengers, also in a critical condition, was transported to hospital by ambulance. It is understood the taxi driver and this passenger were ejected from the vehicle.
All other passengers of the taxi and the driver of the bakkie sustained minor to moderate injuries. They were treated and transported to local hospitals by ambulance as well.
Local authorities were on scene.