Residents of the Enduduzweni Centre for the Blind in Umlazi, and their relatives, protested and police were called to ensure calm prevailed, KwaZulu-Natal social development spokesperson Ncumisa Fandesi said.
She said about 70 people took part in the protests.
"There are many people with disabilities in the province who can benefit from the training provided by the centre and, as a department, we believe it is unfair for a few people to continue to reside at the centre when they have completed their training."
Police spokesperson Thulani Zwane said no one was arrested or injured.
Fandesi said the residents had made allegations against the management, demanding their removal. She said the residents, who had been trained to make a living, were refusing to leave the centre and were preventing other disabled people from being trained.