Johannesburg - Protesters of the Lehae area in the south of Johannesburg outside Lenasia on Tuesday blockaded the Golden Highway with rocks, said the metro police department.
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Chief Superintendent Wayne Minnaar said the road was inaccessible to motorists.
"They should rather use the N1 or the K43 as alternative routes," he said.
The protest started before 05:00. It was not immediately clear what it was about.
Police officers were on the scene, said Minnaar.