Johannesburg - Vlakfontein residents, south of Johannesburg, have blocked the Golden Highway in protest using burning tyres and placing rocks in the road, Johannesburg metro police said on Monday.
It was not immediately clear what the reason for the protest was, spokesperson Chief Superintendent Wayne Minnaar said.
Motorists were urged to use the R554 and K43 as alternative routes.
The protest began around 19:30.