Sportsbet.co.za has predicted a 6-point victory for the Springboks in the clash at the Millennium Stadium.
Wales have failed to beat any of the southern hemisphere's 'Big 3' in their last 22 attempts and have only won once in 27 games since Warren Gatland took over as coach in January 2008. Their only victory came six years ago against Australia and following defeats against the Wallabies and All Blacks this month, they are desperate to beat South Africa.
Wales were unlucky to lose 31-30 to the Springboks in Nelspruit earlier this year, while they also came close to beating the Wallabies a few weeks ago, losing 33-28. During last week's match against the All Blacks in Cardiff, Wales led 16-15 late in the game, before the All Blacks ran riot with three tries in the last 10 minutes to win 34-16.
The Springboks and Wales have faced each other on 29 occasions, with the Boks winning 27 of those. Wales' only victory came in Cardiff in 1999, while there was also a draw in 1970.
Kick-off for Saturday's clash is scheduled for 16:30 (SA time).
Teams:
Wales:
15 Leigh Halfpenny, 14 Alex Cuthbert, 13 Jonathan Davies, 12 Jamie Roberts, 11 Liam Williams, 10 Dan Biggar, 9 Rhys Webb, 8 Taulupe Faletau, 7 Sam Warburton (captain), 6 Dan Lydiate, 5 Alun Wyn Jones, 4 Jake Ball, 3 Samson Lee, 2 Scott Baldwin, 1 Gethin Jenkins
Substitutes: 16 Emyr Phillips, 17 Aaron Jarvis, 18 Rhodri Jones, 19 Luke Charteris, 20 James King, 21 Mike Phillips, 22 Rhys Priestland, 23 Scott Williams
South Africa:
15 Willie le Roux, 14 Cornal Hendricks, 13 Jan Serfontein, 12 Jean de Villiers (captain), 11 Lwazi Mvovo, 10 Pat Lambie, 9 Cobus Reinach, 8 Duane Vermeulen, 7 Teboho “Oupa” Mohoje, 6 Marcell Coetzee, 5 Victor Matfield, 4 Eben Etzebeth, 3 Coenie Oosthuizen, 2 Bismarck du Plessis, 1 Tendai MtawariraSubstitutes: 16 Adriaan Strauss, 17 Trevor Nyakane, 18 Julian Redelinghuys, 19 Lood de Jager, 20 Nizaam Carr, 21 Francois Hougaard, 22 Handré Pollard, 23 Damian de Allende