Sundowns, who go into the tournament after winning last year's Absa Premiership, will take on St. Michel from the Seychelles as they look to qualify for the next round.
Meanwhile, the Amakhosi, who competed in the CAF Champions League and CAF Confederation Cup last year, have been drawn against Township Rollers from Botswana.
Holders ES Setif, Coton Sport, AC Leopards, Al Ahly, TP Mazembe, CS Sfaxien and Esperance were exempt from preliminary round draw.
A total of 58 clubs were in the draw and the matches are set to take place on February 13-15, 2015 and the second legs will be played from February 27-28, March 1, 2015
Full draw:Kaizer Chiefs v Township Rollers
St. Michel v Mamelodi Sundowns
Fomboni Club de Moheil v Big Bullets
C.D Libolo v SM Sanga Balende
Kampala CC v Cosmos de Bafia
Azam v Merrikh
Mbabane Swallows v Zesco United
Sewe Sport v AS Kaloum
USM Alger v Foullah Edifice
AS Pikine v Etoile Filante
Hilal v KMKM
Lydia Ludic B.A v Kabuscorp do Palancas
Sony de Ela Nguema v Semassi de Sokode
MC Eulma v St George
East End Lions v Asante Kotoko
Malakia v Kano Pillars
Real de Banjul v BYC
Raja v Diables Noirs
Mangasport v Bantu
Stade Malien v AS GNN